Absolute Stereochemical Determination of Asymmetric Sulfoxides via Central to Axial Induction of Chirality

被引：18
|
作者：
Gholami, Hadi [1 ]
Zhang, Jun [1 ]
Anyika, Mercy [1 ]
Borhan, Babak [1 ]
机构：
[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 07期
关键词：
VIBRATIONAL CIRCULAR-DICHROISM; OPTICALLY-ACTIVE SULFOXIDES; METHYL SULFOXIDE; CONFIGURATION; SPECTROSCOPY; NMR;
D O I：
10.1021/acs.orglett.7b00495
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The absolute configuration of chiral sulfoxides is determined, by means of host-guest complexation that leads to the induction of axial chirality in an achiral host. The central to axial induction, of helicity is rationalized by a simple recognition, of the relative length and size of the substituents attached to the S-center. This technique is used to determine the absolute configuration of chiral sulfoxides, requiring micrograms of sample, without the need for prefunctionalization.
引用
收藏
页码：1722 / 1725
页数：4
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