The biology of APOL1 with insights into the association between APOL1 variants and chronic kidney disease

被引：11
|
作者：
Madhavan, Sethu M. [1 ]
O'Toole, John F. [1 ]
机构：
[1] Case Western Reserve Univ, Sch Med, Dept Internal Med, MetroHlth Med Syst,Div Nephrol, Cleveland, OH 44109 USA
来源：
CLINICAL AND EXPERIMENTAL NEPHROLOGY | 2014年 / 18卷 / 02期
关键词：
Genetics; Apolipoprotein; HDL; APOL1; Kidney; Focal segmental glomerulosclerosis; HIV; HIV-associated nephropathy; Hypertensive nephrosclerosis; Chronic kidney disease; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; APOLIPOPROTEIN-L GENE; AFRICAN-AMERICANS; PLASMA TRIGLYCERIDES; ALLOGRAFT SURVIVAL; L-I; MYH9; TISSUE; HDL;
D O I：
10.1007/s10157-013-0907-4
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Recent studies have identified genetic variants in APOL1 that may contribute to the increased incidence of kidney disease in populations with African ancestry. Here, we review the biology of APOL1 present in the circulation and localized to the kidney as it may contribute to the pathogenesis of APOL1-associated kidney disease.
引用
收藏
页码：238 / 242
页数：5
相关论文
共 50 条
  • [41] Transcription and translation of APOL1 variants
    Ejaz, Samina
    BIOSCIENCE REPORTS, 2017, 37
  • [42] Hypoxia hits APOL1 in the kidney
    Grampp, Steffen
    Krueger, Rene
    Lauer, Victoria
    Uebel, Sebastian
    Knaup, Karl X.
    Naas, Julia
    Hoeffken, Verena
    Weide, Thomas
    Schiffer, Mario
    Naas, Stephanie
    Schoedel, Johannes
    KIDNEY INTERNATIONAL, 2023, 104 (01) : 53 - 60
  • [43] APOL1 variants and kidney disease. There is no such thing as a free lunch
    Kronenberg, Florian
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2011, 26 (03) : 775 - 778
  • [44] APOL1 and Kidney Disease: New Insights Leading to Novel Therapies
    Freedman, Barry I.
    AMERICAN JOURNAL OF KIDNEY DISEASES, 2015, 66 (01) : 9 - 11
  • [45] APOL1 Expression Does Not Vary With Disease State in Patients with ApoL1 Risk Alleles
    Caza, Tiffany
    Wilson, Jon
    Larsen, Chris
    MODERN PATHOLOGY, 2019, 32
  • [46] APOL1 GENOTYPING AND PROTEINURIC KIDNEY DISEASE IN EUROPE
    Knebelmann, Bertrand
    Bramham, Kate
    Mccafferty, Kieran
    Zaidan, Mohamad
    Torres, Pablo Antonio Urena
    Audard, Vincent
    Boffa, Jean Jacques
    Powell, Thomas
    Shahid, Nauman
    Echeverri, Diego
    Provenzano, Christopher
    Bauman, John
    Zamauskaite, Aurelia
    Delestre-Levai, Irisz
    Yang, Yuan
    Krause, Silva
    Ferreira, Anna Carolina
    Egbuna, Ogo
    Chertow, Glenn
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2023, 38 : I144 - I145
  • [47] Population genetics of chronic kidney disease: The evolving story of APOL1
    Wasser, Walter G.
    Tzur, Shay
    Wolday, Dawit
    Adu, Dwomoa
    Baumstein, Donald
    Rosset, Saharon
    Skorecki, Karl
    JOURNAL OF NEPHROLOGY, 2012, 25 (05) : 603 - 618
  • [48] Association of APOL1 Risk Genotype and Air Pollution for Kidney Disease
    Paranjpe, Ishan
    Chaudhary, Kumardeep
    Paranjpe, Manish
    O'Hagan, Ross
    Manna, Sayan
    Jaladanki, Suraj
    Kapoor, Arjun
    Horowitz, Carol
    DeFelice, Nicholas
    Cooper, Richard
    Glicksberg, Benjamin
    Bottinger, Erwin P.
    Just, Allan C.
    Nadkarni, Girish N.
    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020, 15 (03): : 401 - 403
  • [49] APOL1 Expression Does Not Vary With Disease State in Patients with ApoL1 Risk Alleles
    Caza, Tiffany
    Wilson, Jon
    Larsen, Chris
    LABORATORY INVESTIGATION, 2019, 99
  • [50] The Real World Impact of APOL1 Variants on Kidney Transplantation
    Chandraker, Anil
    TRANSPLANTATION, 2016, 100 (01) : 16 - 17
12345