The biology of APOL1 with insights into the association between APOL1 variants and chronic kidney disease

被引：11
|
作者：
Madhavan, Sethu M. [1 ]
O'Toole, John F. [1 ]
机构：
[1] Case Western Reserve Univ, Sch Med, Dept Internal Med, MetroHlth Med Syst,Div Nephrol, Cleveland, OH 44109 USA
来源：
CLINICAL AND EXPERIMENTAL NEPHROLOGY | 2014年 / 18卷 / 02期
关键词：
Genetics; Apolipoprotein; HDL; APOL1; Kidney; Focal segmental glomerulosclerosis; HIV; HIV-associated nephropathy; Hypertensive nephrosclerosis; Chronic kidney disease; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; APOLIPOPROTEIN-L GENE; AFRICAN-AMERICANS; PLASMA TRIGLYCERIDES; ALLOGRAFT SURVIVAL; L-I; MYH9; TISSUE; HDL;
D O I：
10.1007/s10157-013-0907-4
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Recent studies have identified genetic variants in APOL1 that may contribute to the increased incidence of kidney disease in populations with African ancestry. Here, we review the biology of APOL1 present in the circulation and localized to the kidney as it may contribute to the pathogenesis of APOL1-associated kidney disease.
引用
收藏
页码：238 / 242
页数：5
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