Green Approach to the Design of Functionalized Medicinally Privileged 4-Aryl-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile Scaffold

被引：14
|
作者：
Ilovaisky, Alexey I. [1 ]
Medvedev, Michael G. [1 ]
Merkulova, Valentina M. [1 ]
Elinson, Michail N. [1 ]
Nikishin, Gennady I. [1 ]
机构：
[1] ND Zelinskii Inst Organ Chem, Moscow 119991, Russia
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2014年 / 51卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
ONE-POT SYNTHESIS; IDENTIFICATION; HETEROCYCLES; DERIVATIVES; INHIBITORS; FACILE; WATER;
D O I：
10.1002/jhet.1737
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
On water multicomponent condensation of aromatic aldehydes, malononitrile, and 3-methyl-2-pyrazoline-5-one in the presence of sodium hydroxide as catalyst leads to 6-amino-3-methyl-4-aryl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles in 85-98% yields.
引用
收藏
页码：523 / 526
页数：4
相关论文
共 50 条
  • [41] Sodium ascorbate as an expedient catalyst for green synthesis of polysubstituted 5-aminopyrazole-4-carbonitriles and 6-amino-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles
    Kiyani, Hamzeh
    Bamdad, Maryam
    RESEARCH ON CHEMICAL INTERMEDIATES, 2018, 44 (04) : 2761 - 2778
  • [42] Sodium ascorbate as an expedient catalyst for green synthesis of polysubstituted 5-aminopyrazole-4-carbonitriles and 6-amino-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles
    Hamzeh Kiyani
    Maryam Bamdad
    Research on Chemical Intermediates, 2018, 44 : 2761 - 2778
  • [43] An environmentally friendly synthesis of 1,4-dihydropyrano [2,3-c]pyrazole derivatives catalyzed by tungstate sulfuric acid
    Farahi, Mahnaz
    Karami, Bahador
    Sedighimehr, Iman
    Tanuraghaj, Hamideh Mohamadi
    CHINESE CHEMICAL LETTERS, 2014, 25 (12) : 1580 - 1582
  • [44] An efficient protocol for the one-pot four-component synthesis of 6-amino-1, 4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile derivatives using starch solution as a reaction media
    Vekariya, Rajesh H.
    Patel, Kinjal D.
    Patel, Hitesh D.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2018, 57 (04): : 576 - 582
  • [45] Ulva fasciata-mediated preparation of zinc oxide nanocrystalline for one-pot multicomponent synthesis of 6-amino-3-methyl-4-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
    Cahyana, A. H.
    Nurhayati
    Utomo, B. S. B.
    Ardiansah, B.
    INTERNATIONAL SYMPOSIUM ON CURRENT PROGRESS IN FUNCTIONAL MATERIALS, 2017, 188
  • [46] Spectroscopic and Structural Investigations on Novel 6-Amino-3-Phenyl-4-(Pyridin-4-yl)-2,4-Dihydropyrano[2,3-c] Pyrazole-5-Carbonitrile by FT-IR, NMR, Docking, and DFT Methods
    Kumar, Ratnesh
    Kumar, Abhishek
    Srivastava, Ambrish Kumar
    Brahmachari, Goutam
    Misra, Neeraj
    POLYCYCLIC AROMATIC COMPOUNDS, 2022, 42 (05) : 2288 - 2304
  • [47] Nickel ferrite as a recyclable nanocatalyst for synthesis of novel highly substituted 1,4-dihydropyrano[2,3-c]pyrazole derivatives
    Heravi, Mohammad Reza Poor
    Morsalie, Naheed
    IRANIAN CHEMICAL COMMUNICATION, 2018, 6 (01) : 87 - 96
  • [48] A Practical Catalyst-Free Synthesis of 6-Amino-4 Alkyl/Aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitrile in Aqueous Medium
    Bihani, Manisha
    Bora, Pranjal P.
    Bez, Ghanashyam
    JOURNAL OF CHEMISTRY, 2013, 2013
  • [49] An Efficient Multi-component Synthesis of 6-Amino-3-methyl-4-Aryl-2,4-dihydropyrano[2,3-c]Pyrazole-5-carbonitriles
    Kumar, G. Santhosh
    Kurumurthy, C.
    Veeraswamy, B.
    Rao, P. Sambasiva
    Rao, P. Shanthan
    Narsaiah, B.
    ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 2013, 45 (05) : 429 - 436
  • [50] Isobutyraldehyde in the Synthesis of Isopropyl-substituted 4H-Pyrans, 1,4-Dihydropyrano[2,3-c]pyrazole, 1,4-Dihydropyridines, and Cyclobutane
    V. D. Dyachenko
    A. N. Chernega
    Russian Journal of General Chemistry, 2005, 75 : 952 - 960
12345