Green Approach to the Design of Functionalized Medicinally Privileged 4-Aryl-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile Scaffold

被引：14
|
作者：
Ilovaisky, Alexey I. [1 ]
Medvedev, Michael G. [1 ]
Merkulova, Valentina M. [1 ]
Elinson, Michail N. [1 ]
Nikishin, Gennady I. [1 ]
机构：
[1] ND Zelinskii Inst Organ Chem, Moscow 119991, Russia
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2014年 / 51卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
ONE-POT SYNTHESIS; IDENTIFICATION; HETEROCYCLES; DERIVATIVES; INHIBITORS; FACILE; WATER;
D O I：
10.1002/jhet.1737
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
On water multicomponent condensation of aromatic aldehydes, malononitrile, and 3-methyl-2-pyrazoline-5-one in the presence of sodium hydroxide as catalyst leads to 6-amino-3-methyl-4-aryl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles in 85-98% yields.
引用
收藏
页码：523 / 526
页数：4
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