Green Approach to the Design of Functionalized Medicinally Privileged 4-Aryl-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile Scaffold

被引：14

作者：

Ilovaisky, Alexey I. ^{[1
]}

Medvedev, Michael G. ^{[1
]}

Merkulova, Valentina M. ^{[1
]}

Elinson, Michail N. ^{[1
]}

Nikishin, Gennady I. ^{[1
]}

机构：

[1] ND Zelinskii Inst Organ Chem, Moscow 119991, Russia

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2014年 / 51卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

ONE-POT SYNTHESIS; IDENTIFICATION; HETEROCYCLES; DERIVATIVES; INHIBITORS; FACILE; WATER;

D O I：

10.1002/jhet.1737

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

On water multicomponent condensation of aromatic aldehydes, malononitrile, and 3-methyl-2-pyrazoline-5-one in the presence of sodium hydroxide as catalyst leads to 6-amino-3-methyl-4-aryl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles in 85-98% yields.

引用

页码：523 / 526

页数：4

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