A cooperative Pd-Cu system for direct C-H bond arylation

被引：57

作者：

Lesieur, Mathieu ^{[1
]}

Lazreg, Faima ^{[1
]}

Cazin, Catherine S. J. ^{[1
]}

机构：

[1] Univ St Andrews, EaStCHEM Sch Chem, St Andrews KY16 9ST, Fife, Scotland

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 64期

关键词：

CROSS-COUPLING REACTIONS; SUZUKI-MIYAURA; VINYL HALIDES; PALLADIUM; COMPLEXES; REAGENTS; CATALYST; SUBSTITUTIONS; HETEROARENES; ACTIVATION;

D O I：

10.1039/c4cc03201b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and efficient method for C-H arylation using well-defined Pd- and Cu-NHC systems has been developed. This process promotes the challenging construction of C-C bonds from arenes or heteroarenes using aryl bromides and chlorides. Mechanistic studies show that [Cu(OH)(NHC)] plays a key role in the C-H activation and is involved in the transmetallation with the Pd-NHC co-catalyst.

引用

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页码：8927 / 8929

页数：3

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