Research Progress on Reversing Multidrug Resistance in Tumors by Using Chinese Medicine

被引：18
|
作者：
Zhao, Huan-dong [1 ,4 ]
Xie, Hong-juan [2 ]
Li, Jian [1 ]
Ren, Cai-ping [3 ]
Chen, Yu-xiang [4 ]
机构：
[1] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Nanobiol Technol, Changsha 410008, Hunan, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Pharm, Shanghai 200336, Peoples R China
[3] Cent S Univ, Sch Basic Med Sci, Chinese Minist Hlth, Canc Res Inst,Collaborat Innovat Ctr Canc Med,Key, Changsha 410078, Hunan, Peoples R China
[4] Cent S Univ, Sch Pharm, Changsha 410013, Hunan, Peoples R China
来源：
CHINESE JOURNAL OF INTEGRATIVE MEDICINE | 2018年 / 24卷 / 06期
基金：
中国国家自然科学基金;
关键词：
tumor; multidrug resistance; reversal agents; Chinese medicine; BREAST-CANCER CELLS; P-GLYCOPROTEIN; DRUG-RESISTANCE; IN-VITRO; GAMBOGIC ACID; CURCUMIN; RESVERATROL; TETRANDRINE; EXPRESSION; PATHWAY;
D O I：
10.1007/s11655-018-2910-1
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Multidrug resistance (MDR) is a major cause of cancer chemotherapy failure, and it is important to develop suitable reversal agents to overcome MDR. A majority of chemical reversal agents have acceptable reversal effects. However, the toxicity and adverse reactions associated with these agents restricts their clinical use. Chinese medicines (CMs) have lower toxicities and adverse reactions and are associated with multiple components, multiple targets and reduced toxicity. CMs have several advantages and could reverse MDR, decrease drug dosage, enhance patient compliance and increase efficacy. This review summarizes the current progress of CM reversal agents..
引用
收藏
页码：474 / 480
页数：7
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