Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance

被引：2

作者：

Deng, Zhuo-fen ^{[1
,2
]}

Bakunina, Irina ^{[3
]}

Yu, Hua ^{[4
]}

Han, Jaehong ^{[5
,6
]}

Doemling, Alexander ^{[7
]}

Ferreira, Maria-Jose U. ^{[8
]}

Zhang, Jian-ye ^{[1
,2
]}

机构：

[1] Guangzhou Med Univ, Sch Pharmaceut Sci, State & NMPA Key Lab Resp Dis, Key Lab Mol Target & Clin Pharmacol, Guangzhou, Peoples R China

[2] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou, Peoples R China

[3] Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, Vladivostok, Russia

[4] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[5] Chung Ang Univ, Metalloenzyme Res Grp, Anseong, South Korea

[6] Chung Ang Univ, Dept Plant Sci & Technol, Anseong, South Korea

[7] Univ Groningen, Dept Pharm, Groningen, Netherlands

[8] Univ Lisbon, Fac Pharm, Res Inst Med IMed ULisboa, Lisbon, Portugal

来源：

FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

cancer; chemotherapy; multidrug resistance; natural products; diterpenoids; P-GLYCOPROTEIN MODULATORS; EUPHORBIA FACTOR L1; PSEUDOLARIC-ACID-B; JATROPHANE DITERPENOIDS; MOUSE LYMPHOMA; MACROCYCLIC DITERPENES; BIOLOGICAL EVALUATION; POTENT MODULATORS; TAXUS-CUSPIDATA; CANCER-CELLS;

D O I：

10.3389/fphar.2022.815603

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique advantages in reversing MDR, among which diterpenoids have attracted great attention of the researchers around the world. This review article summarizes and discusses the research progress on diterpenoids in reversing MDR.

引用

页数：14

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