Synthesis of some novel pyrazoline-thiazole hybrids and their antimicrobial activities

被引：16
|
作者：
Masoud, Doaa M. [1 ]
Azzam, Rasha A. [1 ]
Hamdy, Fatma [1 ]
Mekawey, Amal A., I [2 ]
Abdel-Aziz, Hatem A. [3 ]
机构：
[1] Helwan Univ, Chem Dept, Fac Sci, Cairo, Egypt
[2] Al Azhar Univ, Reg Ctr Mycol & Biotechnol, Cairo, Egypt
[3] Natl Res Ctr, Dept Appl Organ Chem, POB 12622, Giza, Egypt
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2019年 / 56卷 / 11期
关键词：
IN-VITRO ANTIBACTERIAL; HETEROCYCLIC SYNTHESIS; BIOLOGICAL EVALUATION; REGIOSELECTIVE SYNTHESIS; POTENTIAL ANTIBACTERIAL; ANTIFUNGAL ACTIVITY; DERIVATIVES; ANTICANCER; DESIGN; ACID;
D O I：
10.1002/jhet.3698
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel thiazolyl pyrazolines 7a-h, 9a-f, and 11a-f have been synthesized by the reaction of thioamide derivatives 5a,b with 1-aryl-2-bromoethanones 6a-d, chloroacetones 8a-c, and hydrazonoyl chlorides 10a-c. Additionally, pyrazoles 15a-c and 20 were prepared starting from enaminone 13. These newly synthesized compounds were screened for their in vitro antibacterial activity against four bacterial species. Compound 11b showed a moderate activity against Klebsiella pneumoniae. Compounds 7c and 11c revealed a moderate activity against Pseudomonas aeruginosa. In addition, the antifungal activity of the newly synthesized compounds was determined against five fungal strains. Compounds 7e, 7g, and 11e showed a good activity against Aspergillus flavus and Penicillium expansum.
引用
收藏
页码：3030 / 3041
页数：12
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