Predictors of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma: a case report

被引：9
|
作者：
Cattelan, Anna Maria [2 ]
Mattiolo, Adriana [1 ]
Grassi, Angela [1 ]
Piano, Maria Assunta [1 ]
Sasset, Lolita [3 ]
Trevenzoli, Marco [4 ]
Zanovello, Paola [5 ]
Calabro, Maria Luisa [1 ]
机构：
[1] IOV IRCCS, Veneto Inst Oncol, Immunol & Mol Oncol, Padua, Italy
[2] Azienda Osped & Univ Padova, Infect & Trop Dis, Padua, Italy
[3] ULSS 18 Azienda Osped, Infect Dis, Rovigo, Italy
[4] Univ Padua, Sch Med, Dept Infect & Trop Dis, Padua, Italy
[5] Univ Padua, Dept Surg Oncol & Gastroenterol, Padua, Italy
来源：
INFECTIOUS AGENTS AND CANCER | 2016年 / 11卷
关键词：
Immune reconstitution inflammatory syndrome; IRIS; Kaposi's sarcoma; KS; KS-IRIS; HHV8; KSHV; Biomarker; ANTIRETROVIRAL THERAPY; BIOMARKERS;
D O I：
10.1186/s13027-016-0051-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We present here a case of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma (KS-IRIS) developed in an AIDS patient two months after initiation of antiretroviral therapy (ART). Baseline characteristics of this IRIS-KS case, within a cohort of 12 naive AIDS-KS patients, were analyzed. No statistically significant differences in CD4 cell counts, plasma HIV RNA load, KS clinical staging, human herpesvirus 8 (HHV8) antibody titers and HHV8 load in peripheral blood mononuclear cells and saliva were evidenced. HHV8 load in plasma was found to be significantly higher in the KS-IRIS patient (>6 log(10) genome equivalents/ml, p = 0.01, t-test) compared to the 11 patients with KS regression. This case highlights that measurement of HHV8 load in plasma may be useful to identify patients at risk for KS-IRIS, and that this parameter should be included in the design of larger studies to define KS-IRIS risk predictors.
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页数：4
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