Predictors of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma: a case report

被引：9

作者：

Cattelan, Anna Maria ^{[2
]}

Mattiolo, Adriana ^{[1
]}

Grassi, Angela ^{[1
]}

Piano, Maria Assunta ^{[1
]}

Sasset, Lolita ^{[3
]}

Trevenzoli, Marco ^{[4
]}

Zanovello, Paola ^{[5
]}

Calabro, Maria Luisa ^{[1
]}

机构：

[1] IOV IRCCS, Veneto Inst Oncol, Immunol & Mol Oncol, Padua, Italy

[2] Azienda Osped & Univ Padova, Infect & Trop Dis, Padua, Italy

[3] ULSS 18 Azienda Osped, Infect Dis, Rovigo, Italy

[4] Univ Padua, Sch Med, Dept Infect & Trop Dis, Padua, Italy

[5] Univ Padua, Dept Surg Oncol & Gastroenterol, Padua, Italy

来源：

INFECTIOUS AGENTS AND CANCER | 2016年 / 11卷

关键词：

Immune reconstitution inflammatory syndrome; IRIS; Kaposi's sarcoma; KS; KS-IRIS; HHV8; KSHV; Biomarker; ANTIRETROVIRAL THERAPY; BIOMARKERS;

D O I：

10.1186/s13027-016-0051-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We present here a case of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma (KS-IRIS) developed in an AIDS patient two months after initiation of antiretroviral therapy (ART). Baseline characteristics of this IRIS-KS case, within a cohort of 12 naive AIDS-KS patients, were analyzed. No statistically significant differences in CD4 cell counts, plasma HIV RNA load, KS clinical staging, human herpesvirus 8 (HHV8) antibody titers and HHV8 load in peripheral blood mononuclear cells and saliva were evidenced. HHV8 load in plasma was found to be significantly higher in the KS-IRIS patient (>6 log(10) genome equivalents/ml, p = 0.01, t-test) compared to the 11 patients with KS regression. This case highlights that measurement of HHV8 load in plasma may be useful to identify patients at risk for KS-IRIS, and that this parameter should be included in the design of larger studies to define KS-IRIS risk predictors.

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