Oxidative Stress as the Main Target in Diabetic Retinopathy Pathophysiology

被引：121

作者：

Cecilia, Olvera-Montano ^{[1
]}

Jose Alberto, Castellanos-Gonzalez ^{[2
]}

Jose, Navarro-Partida ^{[3
]}

Ernesto German, Cardona-Munoz ^{[1
]}

Ana Karen, Lopez-Contreras ^{[1
]}

Luis Miguel, Roman-Pintos ^{[4
]}

Ricardo Raul, Robles-Rivera ^{[1
]}

Adolfo Daniel, Rodriguez-Carrizalez ^{[1
]}

机构：

[1] Univ Guadalajara, Hlth Sci Univ Ctr, Dept Physiol, Inst Clin & Expt Therapeut, Guadalajara, Jalisco, Mexico

[2] Mexican Inst Social Secur, Natl Occidental Med Ctr, Specialties Hosp, Dept Ophthalmol, Mexico City, DF, Mexico

[3] Tecnol Monterrey Inst, Sch Med & Hlth Sci, Campus Guadalajara, Monterrey, Mexico

[4] Univ Guadalajara, Univ Ctr Tonala, Dept Physiol, Guadalajara, Jalisco, Mexico

来源：

JOURNAL OF DIABETES RESEARCH | 2019年 / 2019卷

关键词：

ALPHA-LIPOIC ACID; SYNTHASE GENE POLYMORPHISM; RETINAL GANGLION-CELLS; GLYCATION END-PRODUCTS; NITRIC-OXIDE; VITAMIN-E; ZINC SUPPLEMENTATION; ALDOSE REDUCTASE; KAPPA-B; ANTIOXIDANT ACTIVITY;

D O I：

10.1155/2019/8562408

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus (DM) causing vision impairment even at young ages. There are numerous mechanisms involved in its development such as inflammation and cellular degeneration leading to endothelial and neural damage. These mechanisms are interlinked thus worsening the diabetic retinopathy outcome. In this review, we propose oxidative stress as the focus point of this complication onset.

引用

页数：21

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