Dual Stimuli-Responsive Poly(-amino ester) Nanoparticles for On-Demand Burst Release

被引：16

作者：

Lee, Jung Seok ^{[1
,2
]}

Deng, Xiaojian ^{[1
]}

Han, Patrick ^{[2
]}

Cheng, Jianjun ^{[1
]}

机构：

[1] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

[2] Yale Univ, Dept Biomed Engn, New Haven, CT 06520 USA

来源：

MACROMOLECULAR BIOSCIENCE | 2015年 / 15卷 / 09期

关键词：

nanomedicine; on-demand release; pH-sensitive; poly(-amino ester); UV-sensitive; TUMOR-TARGETED DELIVERY; PH-SENSITIVE SYSTEM; HYDROPHOBIC DRUGS; POLY(BETA-AMINO; POLYMERSOMES; PACLITAXEL; MICROPARTICLES; FORMULATION; MICELLES;

D O I：

10.1002/mabi.201500111

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We designed poly(-amino esters) (PBAEs) bearing both UV light- and pH-sensitive groups and used PBAEs to prepare nanoparticles (NPs) that can be utilized for on-demand burst release of guest molecules in response to multiple triggers. Due to the presence of the photo-cleavable group in each repeating unit of PBAE, rapid release of encapsulated model drug could be achieved even with exposures to low intensity UV (10mWcm(-2)). Especially, the burst release was further accelerated by additional UV treatments in the acidic condition showing the combinatory effect of dual stimuli. We believe these PBAE-based NPs can potentially be used to design intelligent controlled release device and nanomedicines.

引用

页码：1314 / 1322

页数：9

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