Dual Stimuli-Responsive Poly(-amino ester) Nanoparticles for On-Demand Burst Release

We designed poly(-amino esters) (PBAEs) bearing both UV light- and pH-sensitive groups and used PBAEs to prepare nanoparticles (NPs) that can be utilized for on-demand burst release of guest molecules in response to multiple triggers. Due to the presence of the photo-cleavable group in each repeating unit of PBAE, rapid release of encapsulated model drug could be achieved even with exposures to low intensity UV (10mWcm(-2)). Especially, the burst release was further accelerated by additional UV treatments in the acidic condition showing the combinatory effect of dual stimuli. We believe these PBAE-based NPs can potentially be used to design intelligent controlled release device and nanomedicines.