Review of the data about the commitment and differentiation of early haematopoietic progenitor cells and changes in the expression of surface antigens is presented. Phenotypic characteristic of different subpopulation of CD34(+)CDw90(+) cells, early progenitors of granulocytes, macrophages, erythroid and megakaryocytic cells (CFU-GEMM, CFU-GM, BFU-E, CFU-E, CFU-Meg etc.) is given. Possible cell targets for malignant transformation in leukemias are discussed.
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Royal Melbourne Hosp, Peter MacCallum Canc Ctr, Div Canc Med, Melbourne, Vic, AustraliaRoyal Melbourne Hosp, Peter MacCallum Canc Ctr, Div Canc Med, Melbourne, Vic, Australia
Herbert, K. E.
Levesque, J. -P.
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Mater Med Res Inst, Brisbane, Qld, Australia
Univ Queensland, Sch Med, Brisbane, Qld, AustraliaRoyal Melbourne Hosp, Peter MacCallum Canc Ctr, Div Canc Med, Melbourne, Vic, Australia
Levesque, J. -P.
Mills, A. K.
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Princess Alexandra Hosp, Div Canc Serv, Brisbane, Qld 4102, AustraliaRoyal Melbourne Hosp, Peter MacCallum Canc Ctr, Div Canc Med, Melbourne, Vic, Australia
Mills, A. K.
Gottlieb, D. J.
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Univ Sydney, Westmead Hosp, Sydney, NSW 2006, AustraliaRoyal Melbourne Hosp, Peter MacCallum Canc Ctr, Div Canc Med, Melbourne, Vic, Australia
Gottlieb, D. J.
Cooney, J.
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Royal Perth Hosp, Perth, WA, AustraliaRoyal Melbourne Hosp, Peter MacCallum Canc Ctr, Div Canc Med, Melbourne, Vic, Australia
Cooney, J.
Szer, J.
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Royal Melbourne Hosp, Dept Clin Haematol, Melbourne, Vic, Australia
Royal Melbourne Hosp, BMT Serv, Melbourne, Vic, AustraliaRoyal Melbourne Hosp, Peter MacCallum Canc Ctr, Div Canc Med, Melbourne, Vic, Australia
Szer, J.
Rasko, J.
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Centenary Inst Camperdown, Gene & Stem Cell Therapy Program, Sydney, NSW, Australia
Royal Prince Alfred Hosp, Sydney, NSW, AustraliaRoyal Melbourne Hosp, Peter MacCallum Canc Ctr, Div Canc Med, Melbourne, Vic, Australia
Rasko, J.
To, L. B.
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IMVS SA Pathol, Adelaide, SA, Australia
Royal Adelaide Hosp, Adelaide, SA 5000, Australia
Univ Adelaide, Adelaide, SA, AustraliaRoyal Melbourne Hosp, Peter MacCallum Canc Ctr, Div Canc Med, Melbourne, Vic, Australia