A thymine-PNA monomer as new isocyanide component in the Ugi reaction: A direct entry to PNA dimers

被引:18
|
作者
Baldoli, C
Giannini, C
Licandro, E
Maiorana, S
Zinzalla, G
机构
[1] Univ Milan, CNR, Ist Sci & Tecnol Mol, I-20133 Milan, Italy
[2] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
[3] Univ Milan, Ctr Eccellenza CISI, I-20133 Milan, Italy
关键词
multicomponent reaction; arene complexes; chromiumtricarbonyl; peptide nucleic acid; isocyanide;
D O I
10.1055/s-2004-822886
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new PNA monomer was synthesized for use as the isocyanide component in a Ugi condensation in order to produce peptide nucleic acid (PNA) dimers also labelled with Cr(CO)(3).
引用
收藏
页码:1044 / 1048
页数:5
相关论文
共 6 条
  • [1] Synthesis of PNA monomers and dimers by Ugi four-component reaction
    Xu, P
    Zhang, T
    Wang, WH
    Zou, XM
    Zhang, X
    Fu, YQ
    [J]. SYNTHESIS-STUTTGART, 2003, (08): : 1171 - 1176
  • [2] Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction
    Wen Hao WANG
    [J]. Chinese Chemical Letters, 2005, (05) : 585 - 588
  • [3] Synthesis of chiral chromium tricarbonyl labeled thymine PNA monomers via the Ugi reaction
    Baldoli, C
    Maiorana, S
    Licandro, E
    Zinzalla, G
    Perdicchia, D
    [J]. ORGANIC LETTERS, 2002, 4 (24) : 4341 - 4344
  • [4] Solid-phase synthesis of PNA monomer by Ugi four-component condensation
    Wang, WH
    Zou, XM
    Zhang, X
    Fu, YQ
    Xu, P
    [J]. CHINESE CHEMICAL LETTERS, 2005, 16 (05) : 585 - 588
  • [5] 1-Hydroxy-2-methyl-2-propyl Isocyanide (HMPI) as a New Convertible Isocyanide for the Ugi Four-Component-Coupling Reaction
    Oikawa, Masato
    Sugamata, Yutaro
    Chiba, Manami
    Fukushima, Koichi
    Ishikawa, Yuichi
    [J]. SYNLETT, 2013, 24 (15) : 2014 - 2018
  • [6] Enzymatic reaction with unnatural substrates:: DNA photolyase (Escherichia coli) recognizes and reverses thymine [2+2] dimers in the DNA strand of a DNA/PNA hybrid duplex
    Ramaiah, D
    Kan, Y
    Koch, T
    Orum, H
    Schuster, GB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) : 12902 - 12905