Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction

被引：2
|
作者：
Wen Hao WANG
机构：
来源：
Chinese Chemical Letters | 2005年 / 05期
关键词：
Peptide nucleic acids (PNA); Ugi four-component condensation reaction (U-4CR); Solid-phase synthesis; Isocyanide;
D O I：
暂无
中图分类号：
O621.25 [];
学科分类号：
070303 ; 081704 ;
摘要：
Peptide nucleic acids (PNA) oligomers were synthesized in most cases by peptide synthesis from N-protected monomers. In this work a new method of obtaining PNA monomer by Ugi four-component condensation reaction was tested by solid-phase synthesis. The Fmoc protected PNA monomer was build up with thymin-1-yl acetic acid, 3-methylbutyl aldehyde, Fmoc protected aminoethyl isocyanide and Gly-Wang resin.
引用
收藏
页码：585 / 588
页数：4
相关论文
共 50 条
  • [1] Solid-phase synthesis of PNA monomer by Ugi four-component condensation
    Wang, WH
    Zou, XM
    Zhang, X
    Fu, YQ
    Xu, P
    [J]. CHINESE CHEMICAL LETTERS, 2005, 16 (05) : 585 - 588
  • [2] Synthesis of PNA monomers and dimers by Ugi four-component reaction
    Xu, P
    Zhang, T
    Wang, WH
    Zou, XM
    Zhang, X
    Fu, YQ
    [J]. SYNTHESIS-STUTTGART, 2003, (08): : 1171 - 1176
  • [3] Solid-phase synthesis of potential protein tyrosine phosphatase inhibitors via the UGI four-component condensation
    Li, ZG
    Yeo, SL
    Pallen, CJ
    Ganesan, A
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (18) : 2443 - 2446
  • [4] Microwave-assisted solid-phase Ugi four-component condensations
    Hoel, AML
    Nielsen, J
    [J]. TETRAHEDRON LETTERS, 1999, 40 (20) : 3941 - 3944
  • [5] The use of the Ugi four-component condensation
    Stefano Marcaccini
    Tomás Torroba
    [J]. Nature Protocols, 2007, 2 : 632 - 639
  • [6] The use of the Ugi four-component condensation
    Marcaccini, Stefano
    Torroba, Tomas
    [J]. NATURE PROTOCOLS, 2007, 2 (03) : 632 - 639
  • [7] Optimization of a solid-phase synthesis of a PNA monomer
    Viirre, RD
    Hudson, RHE
    [J]. ORGANIC LETTERS, 2001, 3 (24) : 3931 - 3934
  • [8] Template synthesis of peptidomimetics composed of aspartic acid moiety by Ugi four-component condensation reaction
    Zhang, X
    Zou, XM
    Xu, P
    [J]. SYNTHETIC COMMUNICATIONS, 2005, 35 (14) : 1881 - 1888
  • [9] Application of the Ugi four-component condensation reaction for the synthesis of α,α- and α,β-dipeptides substituted with fluoroarylalkyl pendent groups
    Shibata, N
    Das, BK
    Takeuchi, Y
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (24): : 4234 - 4236
  • [10] Unimolecular Exciplexes by Ugi Four-Component Reaction
    Ochs, Maria
    Mayer, Bernhard
    Mueller, Thomas J. J.
    [J]. FRONTIERS IN CHEMISTRY, 2019, 7
12345