Solid-phase synthesis of PNA monomer by Ugi four-component condensation

被引：0

作者：

Wang, WH ^{[1
]}

Zou, XM ^{[1
]}

Zhang, X ^{[1
]}

Fu, YQ ^{[1
]}

Xu, P ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, Dept Med Chem, Beijing 100083, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2005年 / 16卷 / 05期

关键词：

peptide nucleic acids (PNA); Ugi four-component condensation reaction (U-4CR); solid-phase synthesis; isocyanide;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Peptide nucleic acids (PNA) oligomers were synthesized in most cases by peptide synthesis from N-protected monomers. In this work a new method of obtaining PNA monomer by Ugi four-component condensation reaction was tested by solid-phase synthesis. The Fmoc protected PNA monomer was build up with thymin-1-yl acetic acid, 3-methylbutyl aldehyde, Fmoc protected aminoethyl isocyanide and Gly-Wang resin.

引用

页码：585 / 588

页数：4

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