Multi-modal label-free imaging based on a femtosecond fiber laser

被引：13
|
作者：
Xie, Ruxin [1 ]
Su, Jue [1 ]
Rentchler, Eric C. [2 ]
Zhang, Ziyan [3 ]
Johnson, Carey K. [2 ]
Shi, Honglian [3 ]
Hui, Rongqing [1 ]
机构：
[1] Univ Kansas, Dept Elect Engn & Comp Sci, Lawrence, KS 66045 USA
[2] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA
[3] Univ Kansas, Dept Pharmacol & Toxicol, Lawrence, KS 66045 USA
来源：
BIOMEDICAL OPTICS EXPRESS | 2014年 / 5卷 / 07期
基金：
美国国家卫生研究院;
关键词：
STOKES-RAMAN SCATTERING; HIGH-SPECTRAL-RESOLUTION; CARS MICROSCOPY; HIGH-SENSITIVITY; LIVE CELLS; SPECTROSCOPY; FLUORESCENCE; OSCILLATOR; EXCITATION; SOLITON;
D O I：
10.1364/BOE.5.002390
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We demonstrate multi-mode microscopy based on a single femtosecond fiber laser. Coherent anti-Stokes Raman scattering (CARS), stimulated Raman scattering (SRS) and photothermal images can be obtained simultaneously with this simplified setup. Distributions of lipid and hemoglobin in sliced mouse brain samples and blood cells are imaged. The dependency of signal amplitude on the pump power and pump modulation frequency is characterized, which allows to isolate the impact from different contributions. (C) 2014 Optical Society of America
引用
收藏
页码：2390 / 2396
页数：7
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