An acetohydroxamate-coordinated oxidovanadium(V) complex derived from pyridinohydrazone ligand with urease inhibitory activity

被引：37
|
作者：
Li, Yanmin [1 ]
Xu, Luyao [1 ]
Duan, Mengmeng [1 ]
Wu, Jiahui [1 ]
Wang, Yinghui [1 ]
Dong, Kexin [1 ]
Han, Moxuan [1 ]
You, Zhonglu [1 ]
机构：
[1] Liaoning Normal Univ, Dept Chem & Chem Engn, Dalian 116029, Peoples R China
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2019年 / 105卷
关键词：
Pyridinohydrazone; Acetohydroxamate; Oxidovanadium(V) complex; Crystal structure; Urease inhibition; HELICOBACTER-PYLORI UREASE; IN-VITRO; MOLECULAR DOCKING; CRYSTAL-STRUCTURES; METAL-COMPLEXES; COPPER(II); DERIVATIVES; BINDING;
D O I：
10.1016/j.inoche.2019.05.011
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new acetohydroxamate coordinated oxidovanadium(V) complex derived from the pyridinohydrazone ligand 2'-(2-hydroxy-4-methoxybenzylidene)nicotinohydrazide (H2L), was prepared and characterized by elemental analysis, IR, UV-vis and H-1 NMR spectra, and single crystal X-ray diffraction. Thermal analysis of the complex was performed. The V atom is in octahedral coordination. The complex has remarkable inhibitory activity on Jack bean urease with IC50 value of 14.9 mu mol.L-1. The interaction mode of the complex with the urease was studied by molecular docking technique.
引用
收藏
页码：212 / 216
页数：5
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