Synthesis, Characterization, and Crystal Structures of Oxidovanadium(V) Complexes Derived from 2-Chloro-N'-(3,5-dichloro-2-hydroxybenzylidene)benzohydrazide with Antimicrobial Activity

Two new oxodovanadium(V) complexes, [VO(L)(OEt)(MeOH)] (I) and [VO(L)(Bha)] EtOH (II), where L is the anion of 2-chloro-N'-(3,5-dichloro-2-hydroxybenzylidene)benzohydrazide (H2L), Bha is the anion of 2-hydroxybenzohydroxamic acid (HBha), were prepared and characterized by IR, UV-Vis andsingle crystal X-ray determination (CIF files CCDC nos. 1840661 (I) and 1840662 (II)). Complex I crystallizes as the monoclinic space group P2(1)/c with unit cell dimensions a = 8.272(1), b = 21.326(2), c = 12.979(1) angstrom, = 107.173(2)degrees, V = 2187.5(4) angstrom(3), Z = 4, R-1 = 0.0811, wR(2) = 0.2152, GOOF = 1.048. ComplexIIcrystallizes as the triclinic space group P with unit cell dimensions a = 7.407(2), b = 14.195(2), c = 14.330(2) angstrom, = 117.262(2)degrees, = 92.947(2)degrees, = 95.771(2)degrees, V = 1324.4(4) angstrom(3), Z = 2, R-1 = 0.0919, wR(2)= 0.1539, GOOF= 0.986. X-ray analysis indicates that the complexes are mononuclear vanadium(V) species, with the V atoms in octahedral coordination. The complexes were evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. The two complexes have from medium to strong activities against B. subtilis, S. aureus, and E.coli.