Allopurinol: A Useful Adjunct to Thiopurine Therapy for Pediatric Ulcerative Colitis in the Biologic Era

被引：5
|
作者：
Ihekweazu, Faith D. [1 ]
Kellermayer, Richard [1 ]
机构：
[1] Baylor Univ, Texas Childrens Hosp, Sect Pediat Gastroenterol, USDA ARS Childrens Nutr Res Ctr, Houston, TX 77030 USA
来源：
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2014年 / 59卷 / 01期
关键词：
6-MMP; 6-thioguanine nucleotide; allopurinol; hepatotoxicity; thioguanine; thiopurines; ulcerative colitis; INFLAMMATORY-BOWEL-DISEASE;
D O I：
10.1097/MPG.0000000000000344
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Thiopurines are used as a maintenance therapy in patients with ulcerative colitis (UC). For some patients the metabolism of thiopurines is unfavorable, leading to increased adverse effects, including hepatotoxicity. There are many reports in the adult literature concerning the manipulation of thiopurine metabolism with allopurinol; however, there is only 1 publication in this respect for pediatric UC. We present 3 pediatric cases of UC wherein the combination of allopurinol and low-dose 6-mercaptopurine allowed for shunting of thiopurine metabolites to a more favorable pattern. This intervention supported clinical remission in all, including one case poorly responsive to infliximab.
引用
收藏
页码：22 / 24
页数：3
相关论文
共 50 条
  • [41] Considerations of Traditional Chinese Medicine as Adjunct Therapy in the Management of Ulcerative Colitis
    Chi Zhang
    Miao Jiang
    Aiping Lu
    Clinical Reviews in Allergy & Immunology, 2013, 44 : 274 - 283
  • [42] Considerations of Traditional Chinese Medicine as Adjunct Therapy in the Management of Ulcerative Colitis
    Zhang, Chi
    Jiang, Miao
    Lu, Aiping
    CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2013, 44 (03) : 274 - 283
  • [43] Oral Tacrolimus Therapy is Useful for Patients with Intractable Ulcerative Colitis
    Inoue, Nagamu
    Saito, Riko
    Matsuoka, Katsuyoshi
    Hisamatsu, Tadakazu
    Okamoto, Susumu
    Ogata, Haruhiko
    Iwao, Yasushi
    Hibi, Toshifumi
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2010, 105 : S415 - S415
  • [44] The Role of Biologic Cycling on Outcomes in Pediatric Ulcerative Colitis: Stratifying Surgical Risk
    Greene, Alicia C.
    Ziegler, Olivia R.
    Mankarious, Marc M.
    Stack, Michael
    Finkelstein, Adam
    Anthony, Favour M.
    Schaefer, Eric W.
    Schaefer, Marc E.
    Kulaylat, Audrey S.
    Kulaylat, Afif N.
    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2024, 239 (05) : S375 - S376
  • [45] Ulcerative Colitis Therapy: Vedolizumab as a First-line Biologic Agent?
    Metzger, Leandra
    ZEITSCHRIFT FUR GASTROENTEROLOGIE, 2022, 60 (03): : 274 - 276
  • [46] MICROBIOME AND EPIGENETIC PREDICTORS OF RESPONSE TO BIOLOGIC THERAPY IN PATIENTS WITH ULCERATIVE COLITIS
    Shah, Rajesh
    Shen, Lanlan
    GASTROENTEROLOGY, 2020, 158 (03) : S68 - S68
  • [47] MICROBIOME AND EPIGENETIC PREDICTORS OF RESPONSE TO BIOLOGIC THERAPY IN PATIENTS WITH ULCERATIVE COLITIS
    Shah, Rajesh
    Shen, Lanlan
    INFLAMMATORY BOWEL DISEASES, 2020, 26 : S41 - S42
  • [48] Cytapheresis therapy for ulcerative colitis in three pediatric patients
    Mori, K
    Yoshihara, T
    Ando, T
    Tsubai, S
    Matsuo, S
    Aoyama, I
    Yamamoto, I
    Kawase, Y
    JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2004, 39 (05): : 549 - 551
  • [49] Emergent and Urgent Surgery for Ulcerative Colitis in the United States in the Minimally Invasive and Biologic Era
    Abd El Aziz, Mohamed A.
    Larson, David W.
    Grass, Fabian
    D'Angelo, Anne-Lise D.
    Kelley, Scott R.
    Raffals, Laura E.
    Mathis, Kellie L.
    Shawki, Sherief
    DISEASES OF THE COLON & RECTUM, 2022, 65 (08) : 1025 - 1033
  • [50] Safe azathioprine treatment in a pediatric ulcerative colitis patient with TPMT*16 by thiopurine metabolite monitoring
    Kim, Hyun-Young
    Kim, Jong-Won
    Kim, Mi Jin
    Lee, Yoo Min
    Kang, Ben
    Choe, Yon Ho
    Lee, Soo-Youn
    CLINICA CHIMICA ACTA, 2014, 437 : 101 - 102
12345