Allopurinol: A Useful Adjunct to Thiopurine Therapy for Pediatric Ulcerative Colitis in the Biologic Era

被引：5

作者：

Ihekweazu, Faith D. ^{[1
]}

Kellermayer, Richard ^{[1
]}

机构：

[1] Baylor Univ, Texas Childrens Hosp, Sect Pediat Gastroenterol, USDA ARS Childrens Nutr Res Ctr, Houston, TX 77030 USA

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2014年 / 59卷 / 01期

关键词：

6-MMP; 6-thioguanine nucleotide; allopurinol; hepatotoxicity; thioguanine; thiopurines; ulcerative colitis; INFLAMMATORY-BOWEL-DISEASE;

D O I：

10.1097/MPG.0000000000000344

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Thiopurines are used as a maintenance therapy in patients with ulcerative colitis (UC). For some patients the metabolism of thiopurines is unfavorable, leading to increased adverse effects, including hepatotoxicity. There are many reports in the adult literature concerning the manipulation of thiopurine metabolism with allopurinol; however, there is only 1 publication in this respect for pediatric UC. We present 3 pediatric cases of UC wherein the combination of allopurinol and low-dose 6-mercaptopurine allowed for shunting of thiopurine metabolites to a more favorable pattern. This intervention supported clinical remission in all, including one case poorly responsive to infliximab.

引用

页码：22 / 24

页数：3

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