Intermediate cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis successfully treated with fluconazole

被引:11
|
作者
Daly, K. [1 ]
De Lima, H. [2 ]
Kato, H. [3 ]
Sordillo, E. M. [4 ,5 ]
Convit, J. [6 ]
Reyes-Jaimes, O. [6 ]
Zerpa, O. [2 ]
Paniz-Mondolfi, A. E. [1 ,6 ,7 ]
机构
[1] Fdn Jacinto Convit, Caracas, Venezuela
[2] Inst Biomed, Div Leishmaniasis, Caracas, Venezuela
[3] Hokkaido Univ, Grad Sch Vet Med, Dept Dis Control, Parasitol Lab, Sapporo, Hokkaido, Japan
[4] Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Univ Hosp, Dept Pathol & Lab Med, New York, NY 10032 USA
[5] Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Univ Hosp, Infect Dis Dev Lab,Dept Med, New York, NY 10032 USA
[6] UCV MPPS IVSS, Inst Biomed, Lab Biochem & Dermatopathol, Caracas, Venezuela
[7] Yale Univ, Sch Med, Med Microbiol Lab, Dept Lab Med, New Haven, CT 06511 USA
基金
日本学术振兴会;
关键词
ORAL FLUCONAZOLE; CHILD; PROMASTIGOTES;
D O I
10.1111/ced.12359
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
American cutaneous leishmaniasis is an endemic anthropozoonosis that exhibits a broad spectrum of clinical presentations. Intermediate/ borderline disseminated cutaneous leishmaniasis is a distinct clinical condition that comprises cutaneous disease of a chronic nature, usually occurring as multiple lesions with or without mucosal involvement. The disease is usually caused by parasites of the subgenus Viannia, frequently occurs in context of an underlying disease, and is often resistant to standard antileishmanial therapy. We report a case that was refractory to standard therapy and other second-line drugs, but resolved after treatment with fluconazole, and review the use of fluconazole as a second-line drug in children.
引用
收藏
页码:708 / 712
页数:5
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