Proline-Catalyzed Dehydrogenative Cross-Coupling Reaction between Chromene and Aldehydes

被引：7
|
作者：
Wu, Zi-Jun [1 ]
Qian, Jian [2 ]
Wang, Tian-Tian [1 ]
Huang, Zhi-Zhen [1 ,3 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310028, Zhejiang, Peoples R China
[2] Zhejiang Jianye Chem Co Ltd, Hangzhou 311604, Zhejiang, Peoples R China
[3] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
SYNLETT | 2014年 / 25卷 / 14期
基金：
中国国家自然科学基金;
关键词：
C-H functionalization; DCC reaction; organocatalysis; oxidation; chromene; C-H ACTIVATION; ALPHA-ALKYLATION; TERTIARY-AMINES; TETRAHYDROISOQUINOLINES; KETONES; ETHERS; BONDS; ACID; CDC;
D O I：
10.1055/s-0034-1378496
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unprecedented DCC reaction between chromene and aldehydes catalyzed by proline has been developed via direct C-H functionalization. A plausible mechanism using DDQ to activate alpha-C-H of chromene and proline to activate aldehyde is also proposed.
引用
收藏
页码：2072 / 2074
页数：3
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