A new sesquiterpene lactone glucoside with inhibitory effect on K562 cells from Ixeris sonchifolia (Bge) Hance

被引:17
|
作者
He, W. -F.
Xu, B. -B.
Pan, J. -C.
Lu, J. -C.
Song, S. -J.
Xu, S. -X. [1 ]
机构
[1] Wenzhou Med Coll, Sch Pharm, Wenzhou 325035, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China
关键词
Ixeris sonchifolia; compositae; Ixerin Z(A); K-562; cells;
D O I
10.1080/10286020500532140
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
A new minor sesquiterpene lactone glucoside, ixerin Z(A) ( 1), together with 16 known compounds, were isolated from the whole plants of Ixeris sonchifolia (Bge) Hance. The structure of 1 was elucidated as 1(10),3,11(13)-guaiatriene-12,6-olide-2-one-3-O-[6 '-(p-metheoxyphenylacetyl)]-beta-glucopyranoside on the basis of spectroscopic and chemical evidence. Compound 1 exhibited an inhibitory effect on K-562 cells.
引用
收藏
页码:481 / 484
页数:4
相关论文
共 50 条
  • [41] Inhibitory effect of curcumin on proliferation of K562 cells involves down-regulation of p210bcr/abl-initiated Ras signal transduction pathway
    Wu, LX
    Xu, JH
    Wu, GH
    Chen, YZ
    ACTA PHARMACOLOGICA SINICA, 2003, 24 (11) : 1155 - 1160
  • [42] Inhibitory Effects of JEUD-38, a New Sesquiterpene Lactone from Inula japonica Thunb, on LPS-Induced iNOS Expression in RAW264.7 Cells
    Xiaoqing Wang
    Sheng-An Tang
    Ran Wang
    Yuling Qiu
    Meihua Jin
    Dexin Kong
    Inflammation, 2015, 38 : 941 - 948
  • [43] Inhibitory Effects of JEUD-38, a New Sesquiterpene Lactone from Inula japonica Thunb, on LPS-Induced iNOS Expression in RAW264.7 Cells
    Wang, Xiaoqing
    Tang, Sheng-An
    Wang, Ran
    Qiu, Yuling
    Jin, Meihua
    Kong, Dexin
    INFLAMMATION, 2015, 38 (03) : 941 - 948
  • [44] Effect of IFN-gamma production on genetically modified K562 cells and CD34 positive cells from chronic myelogenous leukemia patients.
    Salesse, S
    PigeonnierLagarde, V
    Mahon, FX
    Mazurier, F
    Reiffers, J
    deVerneuil, H
    EXPERIMENTAL HEMATOLOGY, 1996, 24 (09) : 587 - 587
  • [45] Purification and characterization of a new D-galactose-specific lectin from the housefly, Musca domestica, and its antiproliferative effect on human K562 and MCF-7 tumor cells
    Cao, X.
    Sun, Y.
    Wang, C.
    Zeng, B.
    JOURNAL OF INSECT SCIENCE, 2010, 10
  • [46] Selective effect of unductors of apoptosis on the phosphorylation state and the endoribonuclease activity of 26S proteasomes from different cellular compartments of K562 cells
    Tsimokha, AS
    Kulichkova, VA
    Mittenberg, AG
    Evteeva, IN
    Volkova, IV
    Ermolaeva, JB
    Konstantinova, IM
    FEBS JOURNAL, 2005, 272 : 47 - 47
  • [47] Anti-inflammatory effect of D-pinitol isolated from the leaves of Colutea cilicica Boiss et Bal. on K562 cells
    Eser, Ferda
    Altundag, Ergul Mutlu
    Gedik, Gulsah
    Demirtas, Ibrahim
    Onal, Adem
    Selvi, Bedrettin
    TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, 2017, 42 (04): : 445 - 450
  • [48] FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release
    Rolin, Johannes
    Sand, Kristin L.
    Knudsen, Eirunn
    Maghazachi, Azzam A.
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2010, 59 (04) : 575 - 586
  • [49] FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release
    Johannes Rolin
    Kristin L. Sand
    Eirunn Knudsen
    Azzam A. Maghazachi
    Cancer Immunology, Immunotherapy, 2010, 59 : 575 - 586
  • [50] Proanthocyanidin from grape seeds enhances doxorubicin-induced antitumor effect and reverses drug resistance in doxorubicin-resistant K562/DOX cells
    Zhang, XY
    Li, WG
    Wu, YJ
    Bai, DC
    Liu, NF
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2005, 83 (03) : 309 - 318