Prion Topology and Toxicity

被引：12
|
作者：
Aguzzi, Adriano [1 ]
Steele, Andrew D. [2 ]
机构：
[1] Univ Zurich Hosp, Inst Neuropathol, CH-8091 Zurich, Switzerland
[2] CALTECH, Div Biol, Pasadena, CA 91125 USA
来源：
CELL | 2009年 / 137卷 / 06期
关键词：
PROTEIN; NEUROTOXICITY; NEURODEGENERATION;
D O I：
10.1016/j.cell.2009.05.041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inactivation of mahogunin, an E3 ubiquitin ligase, causes a spongiform encephalopathy resembling prion disease. Chakrabarti and Hegde (2009) now report that prion proteins with aberrant topologies inactivate mahogunin, providing a plausible explanation for certain aspects of prion pathology.
引用
收藏
页码：994 / 996
页数：4
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