Prion protein - mediator of toxicity in multiple proteinopathies

被引：4
|
作者：
Ayers, Jacob, I [1 ,2 ]
Prusiner, Stanley B. [1 ,2 ,3 ]
机构：
[1] Univ Calif San Francisco, Inst Neurodegenerat Dis, Weill Inst Neurosci, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
来源：
NATURE REVIEWS NEUROLOGY | 2020年 / 16卷 / 04期
关键词：
D O I：
10.1038/s41582-020-0332-8
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A new study shows that interactions of the cellular prion protein with amyloid-beta, tau and alpha-synuclein oligomers are important in mediating the toxicity of these proteins in Alzheimer disease and Parkinson disease. The findings suggest a shared pathway that could be a therapeutic target common to multiple neurodegenerative diseases.
引用
收藏
页码：187 / 188
页数：2
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