Driving the Morita-Baylis-Hillman Reaction to a Multicomponent Organic Transformation

被引：2
|
作者：
Guillouzic, Anne-Francoise [1 ]
Montel, Sonia [1 ]
Laborde, Coralie [1 ]
Volle, Jean-Noel [1 ]
Pirat, Jean-Luc [1 ]
Virieux, David [1 ]
机构：
[1] Ecole Natl Super Chim Montpellier, Inst Charles Gerhardt, UMR 5253, F-34296 Montpellier 5, France
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 04期
关键词：
Multicomponent reactions; Domino reactions; Phosphorus; Alkenes; Aldehydes; STEREOSELECTIVE-SYNTHESIS; HYDROPHOSPHONYLATION; PRODUCT; SUBSTITUTION; PHOSPHONATES; CARBONATES; CHEMISTRY; ALKENES; ALKYNES; ACCESS;
D O I：
10.1002/ejoc.201301226
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The combination of a trivalent phosphorus reagent with an aldehyde and a Michael olefin in the presence of water led to the formation of functionalized phosphine oxides. This approach turned the Lewis base organocatalyzed Morita-Baylis-Hillman reaction into a multicomponent organic transformation to provide rapid access to polyfunctionalized molecules.
引用
收藏
页码：788 / 796
页数：9
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