Calixcephems: clustered cephalosporins analogous to calixpenams as novel potential anti-MRSA agents

被引：14

作者：

Pur, Fazel Nasuhi ^{[1
,2
]}

Dilmaghani, Karim Akbari ^{[1
]}

机构：

[1] Urmia Univ, Fac Sci, Dept Chem, Orumiyeh, Iran

[2] Urmia Univ Med Sci, Hlth Technol Incubator Ctr, Orumiyeh, Iran

来源：

TURKISH JOURNAL OF CHEMISTRY | 2014年 / 38卷 / 05期

关键词：

Calixcephem; calixpenam; calixarene; cluster; Staphylococcus aureus; ANTIBIOTICS;

D O I：

10.3906/kim-1403-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two novel clusters of cephalosporin based on calixarene were synthesized directly or by ring expansion of the penicillin arms of calixpenams to the corresponding cephem arms via sulfoxide intermediates. Antibiotic tests showed that calixcephems have a noteworthy increase in antibacterial activity against methicillin-resistant strains of Staphylococcus aureus (MRSA) with respect to parent calixpenams and their corresponding single cephems.

引用

页码：850 / 858

页数：9

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