Stereoselective synthesis of novel anti-MRSA tricyclic carbapenems (trinems)

被引：31
|
作者：
Kanno, O [1 ]
Kawamoto, I [1 ]
机构：
[1] Sankyo Co Ltd, Med Chem Res Labs, Shinagawa Ku, Tokyo 1408710, Japan
来源：
TETRAHEDRON | 2000年 / 56卷 / 31期
关键词：
trinems; stereoselective synthesis; Mitsunobu reaction; MRSA;
D O I：
10.1016/S0040-4020(00)00413-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(4S)-Hydroxymethyltrinem 3 was prepared via stereoselective aldol-type reaction with optically pure (R)-2-t-butyldimethylsilyloxymethylcyclohexanone ((R)-16). (4S)-Hydroxymethyltrinem 3 was converted into various kinds of trinem derivatives with anti-MRSA activity by using the Mitsunobu reaction. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：5639 / 5648
页数：10
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