Surface engineering of macrophages with nucleic acid aptamers for the capture of circulating tumor cells

被引：24
|
作者：
Sugimoto, Shunsuke [1 ]
Moriyama, Rui [1 ,2 ]
Mori, Takeshi [3 ]
Iwasaki, Yasuhiko [1 ]
机构：
[1] Kansai Univ, Dept Chem & Mat Engn, Fac Chem Mat & Bioengn, Suita, Osaka 5648680, Japan
[2] Kyushu Inst Technol, Dept Appl Chem, Tobata Ku, Kitakyushu, Fukuoka 8040015, Japan
[3] Kyushu Univ, Dept Appl Chem, Fac Engn, Fukuoka 8128581, Japan
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 98期
关键词：
N-ACETYLNEURAMINIC ACID; BIOSYNTHESIS; METASTASIS; SELEX;
D O I：
10.1039/c5cc06211j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In order to enhance the interactions between macrophages and cancer cells, thiol-terminated nucleic acid aptamers were immobilized on methacryloyl-functionalised carbohydrates of macrophages. The adhesion of cancer cells on the surface modified macrophages was significantly accelerated.
引用
收藏
页码：17428 / 17430
页数：3
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