Surface engineering of macrophages with nucleic acid aptamers for the capture of circulating tumor cells

被引：24

作者：

Sugimoto, Shunsuke ^{[1
]}

Moriyama, Rui ^{[1
,2
]}

Mori, Takeshi ^{[3
]}

Iwasaki, Yasuhiko ^{[1
]}

机构：

[1] Kansai Univ, Dept Chem & Mat Engn, Fac Chem Mat & Bioengn, Suita, Osaka 5648680, Japan

[2] Kyushu Inst Technol, Dept Appl Chem, Tobata Ku, Kitakyushu, Fukuoka 8040015, Japan

[3] Kyushu Univ, Dept Appl Chem, Fac Engn, Fukuoka 8128581, Japan

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 98期

关键词：

N-ACETYLNEURAMINIC ACID; BIOSYNTHESIS; METASTASIS; SELEX;

D O I：

10.1039/c5cc06211j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to enhance the interactions between macrophages and cancer cells, thiol-terminated nucleic acid aptamers were immobilized on methacryloyl-functionalised carbohydrates of macrophages. The adhesion of cancer cells on the surface modified macrophages was significantly accelerated.

引用

页码：17428 / 17430

页数：3

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