Facile synthesis of 3(2H)-furanones

被引：6
|
作者：
Panda, Niranjan [1 ]
Nayak, Dinesh K. [1 ]
机构：
[1] Natl Inst Technol Rourkela, Dept Chem, Rourkela 769008, Odisha, India
来源：
MONATSHEFTE FUR CHEMIE | 2018年 / 149卷 / 06期
关键词：
3(2H)-furanones; 4-Hydroxyalkynone; Annulation; Cu-catalysis; Bullatenone; HIGHLY SUBSTITUTED 3(2H)-FURANONES; TERMINAL ALKYNES; ALPHA; BETA-ACETYLENIC KETONES; INTRAMOLECULAR CYCLIZATION; PROPARGYLIC ALCOHOLS; EFFICIENT SYNTHESIS; COUPLING REACTION; DOMINO REACTION; ACID-CHLORIDES; SIDE-CHAIN;
D O I：
10.1007/s00706-018-2152-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A practical method for the synthesis of 3(2H)-furanones including the bullatenone was described. Intramolecular cyclization of 4-hydroxyalkynones in the presence of KOH affords the biologically potent furanones in moderate-to-good yield at room temperature. Synthesis of 4-hydroxyalkynones from the reaction of acid chloride and terminal alkyne in the presence of copper iodide at room temperature was also reported. [GRAPHICS] .
引用
收藏
页码：1093 / 1100
页数：8
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