Facile synthesis of 3(2H)-furanones

被引：6

作者：

Panda, Niranjan ^{[1
]}

Nayak, Dinesh K. ^{[1
]}

机构：

[1] Natl Inst Technol Rourkela, Dept Chem, Rourkela 769008, Odisha, India

来源：

MONATSHEFTE FUR CHEMIE | 2018年 / 149卷 / 06期

关键词：

3(2H)-furanones; 4-Hydroxyalkynone; Annulation; Cu-catalysis; Bullatenone; HIGHLY SUBSTITUTED 3(2H)-FURANONES; TERMINAL ALKYNES; ALPHA; BETA-ACETYLENIC KETONES; INTRAMOLECULAR CYCLIZATION; PROPARGYLIC ALCOHOLS; EFFICIENT SYNTHESIS; COUPLING REACTION; DOMINO REACTION; ACID-CHLORIDES; SIDE-CHAIN;

D O I：

10.1007/s00706-018-2152-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A practical method for the synthesis of 3(2H)-furanones including the bullatenone was described. Intramolecular cyclization of 4-hydroxyalkynones in the presence of KOH affords the biologically potent furanones in moderate-to-good yield at room temperature. Synthesis of 4-hydroxyalkynones from the reaction of acid chloride and terminal alkyne in the presence of copper iodide at room temperature was also reported. [GRAPHICS] .

引用

页码：1093 / 1100

页数：8

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