One pot synthesis of novel dispiro[oxindole-thiazolidinedione/thioxo-thiazolidinone/dihydro pyrazolone]-pyrrolidines via 1,3-dipolar cycloaddition reaction of azomethine ylides

被引：17
|
作者：
Ponnala, Shashikanth
Kumar, Rishi
Maulik, Prakas R.
Sahu, Devi Prasad [1 ]
机构：
[1] Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226001, Uttar Pradesh, India
[2] Cent Drug Res Inst, Div Mol & Struct Biol, Lucknow 226001, Uttar Pradesh, India
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2006年 / 43卷 / 06期
关键词：
D O I：
10.1002/jhet.5570430631
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel dispiro[oxindole-thiazolidinedione]pyrrolidine, dispiro[oxindole-thioxothiazolidinone]pyrrolidine, dispiro[oxindole-dihydro-pyrazolone]pyrrolidine were synthesized by both regio- and stereoselective 1,3-dipolar cycloaddition reaction of azomethine ylide generated from amino acid and amino acid ester with pi-deficient alkenes in a single pot protocol in good yield. X-ray crystallographic studies established orthogonal disposition between spiro-oxindole and spiro -thiazolidinedione rings in 4a and 5a.
引用
收藏
页码：1635 / 1640
页数：6
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