Effect of oxytocin on growth hormone release in vitro

被引：11
|
作者：
Hulting, AL
Grenback, E
Pineda, J
Coya, R
Hokfelt, T
Meister, B
UvnasMoberg, K
机构：
[1] KAROLINSKA INST, DEPT NEUROSCI, S-17177 STOCKHOLM, SWEDEN
[2] KAROLINSKA HOSP, DEPT ENDOCRINOL, S-17176 STOCKHOLM, SWEDEN
[3] KAROLINSKA INST, DEPT PHARMACOL, S-17177 STOCKHOLM, SWEDEN
来源：
REGULATORY PEPTIDES | 1996年 / 67卷 / 02期
关键词：
anterior pituitary; oxytocin; oxytocin antagonist; growth hormone; galanin; cholecystokinin; rat;
D O I：
10.1016/S0167-0115(96)00112-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effect of oxytocin (OT) on growth hormone (GH) secretion was investigated using dispersed rat anterior pituitary cells. OT dose-dependently inhibited GH secretion as well as GHRH-stimulated GH release. The inhibitory actions of OT on GH release were totally abolished by pretreatment with the OT-antagonist VAP 259. The peptides galanin and cholecystokinin did not affect the OT-induced inhibition on basal or GHRH-stimulated GH release. Several possible mechanisms by which OT may influence GH release are discussed.
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页码：69 / 73
页数：5
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