Effect of oxytocin on growth hormone release in vitro

被引：11
|
作者：
Hulting, AL
Grenback, E
Pineda, J
Coya, R
Hokfelt, T
Meister, B
UvnasMoberg, K
机构：
[1] KAROLINSKA INST, DEPT NEUROSCI, S-17177 STOCKHOLM, SWEDEN
[2] KAROLINSKA HOSP, DEPT ENDOCRINOL, S-17176 STOCKHOLM, SWEDEN
[3] KAROLINSKA INST, DEPT PHARMACOL, S-17177 STOCKHOLM, SWEDEN
来源：
REGULATORY PEPTIDES | 1996年 / 67卷 / 02期
关键词：
anterior pituitary; oxytocin; oxytocin antagonist; growth hormone; galanin; cholecystokinin; rat;
D O I：
10.1016/S0167-0115(96)00112-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effect of oxytocin (OT) on growth hormone (GH) secretion was investigated using dispersed rat anterior pituitary cells. OT dose-dependently inhibited GH secretion as well as GHRH-stimulated GH release. The inhibitory actions of OT on GH release were totally abolished by pretreatment with the OT-antagonist VAP 259. The peptides galanin and cholecystokinin did not affect the OT-induced inhibition on basal or GHRH-stimulated GH release. Several possible mechanisms by which OT may influence GH release are discussed.
引用
收藏
页码：69 / 73
页数：5
相关论文
共 50 条
  • [31] INHIBITION OF RELEASE OF GROWTH-HORMONE IN-VITRO BY ALPHA-MELANOCYTE STIMULATING HORMONE
    SCHALLY, AV
    ARIMURA, A
    KASTIN, AJ
    UEHARA, T
    COY, DH
    COY, EJ
    TAKAHARA, J
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1973, 52 (04) : 1314 - 1319
  • [32] INHIBITION OF GROWTH-HORMONE AND THYROTROPIN RELEASE BY GROWTH HORMONE-RELEASE INHIBITING HORMONE
    BELANGER, A
    LABRIE, F
    BORGEAT, P
    SAVARY, M
    COTE, J
    DROUIN, J
    SCHALLY, AV
    COY, DH
    COY, EJ
    IMMER, H
    SESTANJ, K
    NELSON, V
    GOTZ, M
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1974, 1 (05) : 329 - 339
  • [33] GROWTH HORMONE RELEASE INHIBITING HORMONE
    KAHN, A
    JOURNAL OF THE ARKANSAS MEDICAL SOCIETY, 1974, 71 (04): : 161 - 161
  • [34] INHIBITION OF IN VITRO RELEASE OF THYREOTROPHIN BY ANALOGUE OF OXYTOCIN 3-VALINE-OXYTOCIN
    SCHREIBER, V
    ECKERTOVA, A
    KMENTOVA, V
    EXPERIENTIA, 1964, 20 (12): : 673 - +
  • [35] Galanin influences on vasopressin and oxytocin release: In vitro studies
    Izdebska, K.
    Ciosek, J.
    NEUROPEPTIDES, 2010, 44 (04) : 341 - 348
  • [36] EFFECT OF GROWTH-HORMONE-RELEASING-FACTOR ON GROWTH-HORMONE AND SOMATOSTATIN RELEASE IN OBESE CHILDREN
    MAXIMCIUC, G
    ROSSKAMP, R
    ACTA ENDOCRINOLOGICA, 1985, 109 : 26 - 26
  • [37] EFFECT OF FENFLURAMINE UPON HUMAN GROWTH-HORMONE RELEASE
    SULAIMAN, WR
    PARK, DM
    JOHNSON, RH
    SCOTTISH MEDICAL JOURNAL, 1972, 17 (11) : 377 - &
  • [38] EFFECT OF GROWTH-HORMONE ON ACUTE GLUCAGON AND INSULIN RELEASE
    SIREK, A
    VRANIC, M
    SIREK, OV
    VIGAS, M
    POLICOVA, Z
    AMERICAN JOURNAL OF PHYSIOLOGY, 1979, 237 (02): : E107 - E112
  • [39] HUMAN GROWTH HORMONE RELEASE IN SLEEP - EFFECT OF DAYTINE EXERCISE
    ZIR, LM
    SMITH, RA
    PARKER, DC
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1971, 32 (05): : 662 - +
  • [40] EFFECT OF PENTAGASTRIN ON GROWTH-HORMONE AND SOMATOSTATIN RELEASE IN CHILDREN
    ROSSKAMP, R
    BECKER, M
    ACTA ENDOCRINOLOGICA, 1985, 109 : 100 - 100
12345