Combinatorial therapies for rescuing myotonic dystrophy type 1 skeletal muscle defects

被引：4
|
作者：
Ravel-Chapuis, Aymeric [1 ,2 ]
Jasmin, Bernard J. [1 ,2 ]
机构：
[1] Univ Ottawa, Fac Med, Dept Cellular & Mol Med, Ottawa, ON, Canada
[2] Univ Ottawa, Fac Med, Er Poulin Ctr Neuromuscular Dis, Ottawa, ON, Canada
来源：
TRENDS IN MOLECULAR MEDICINE | 2022年 / 28卷 / 06期
关键词：
D O I：
10.1016/j.molmed.2022.04.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Myotonic dystrophy type 1 (DM1) is a multisystemic disorder for which there is no cure. In recent years, progress has been made in defining disease mechanisms and in developing novel therapies, especially for skeletal muscle defects. Here, we highlight the potential of activating AMP-activated protein kinase (AMPK) with different approaches in combinatorial therapies.
引用
收藏
页码：439 / 442
页数：4
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