Synthesis of lndolizine Derivatives by Pd-Catalyzed Oxidative Carbonylation

被引：51

作者：

Xu, Tongyu ^{[1
]}

Alper, Howard ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem & Biomol Sci, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 18期

基金：

加拿大自然科学与工程研究理事会;

关键词：

HIGHLY EFFICIENT SYNTHESIS; FUNCTIONALIZED INDOLIZINES; HETEROCYCLE FORMATION; H BONDS; PALLADIUM; CYCLOISOMERIZATION; CO; CYCLIZATION; CASCADE; ALKOXYCARBONYLATION;

D O I：

10.1021/acs.orglett.5b02220

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of indolizine derivatives by palladium-catalyzed oxidative carbonylation of propargylic pyridines has been developed. The reaction can be conducted at room temperature and under 3 bar of CO in the presence of Pd-2(dba)(3) or Pd/C. The catalyst Pd/C could be easily removed from the reaction and recycled.

引用

页码：4526 / 4529

页数：4

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