Synthesis of lndolizine Derivatives by Pd-Catalyzed Oxidative Carbonylation

被引：51
|
作者：
Xu, Tongyu [1 ]
Alper, Howard [1 ]
机构：
[1] Univ Ottawa, Dept Chem & Biomol Sci, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 18期
基金：
加拿大自然科学与工程研究理事会;
关键词：
HIGHLY EFFICIENT SYNTHESIS; FUNCTIONALIZED INDOLIZINES; HETEROCYCLE FORMATION; H BONDS; PALLADIUM; CYCLOISOMERIZATION; CO; CYCLIZATION; CASCADE; ALKOXYCARBONYLATION;
D O I：
10.1021/acs.orglett.5b02220
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of indolizine derivatives by palladium-catalyzed oxidative carbonylation of propargylic pyridines has been developed. The reaction can be conducted at room temperature and under 3 bar of CO in the presence of Pd-2(dba)(3) or Pd/C. The catalyst Pd/C could be easily removed from the reaction and recycled.
引用
收藏
页码：4526 / 4529
页数：4
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