Protein structure-based design, synthesis strategy and in vitro pharmacological characterization of estrogen receptor α and β selective compounds

被引：0
|
作者：
Hillisch, A [1 ]
Peters, O [1 ]
Kosemund, D [1 ]
Müller, G [1 ]
Walter, A [1 ]
Elger, W [1 ]
Fritzemeier, KH [1 ]
机构：
[1] EnTec Ltd, D-07745 Jena, Germany
来源：
NEW MOLECULAR MECHANISMS OF ESTROGEN ACTION AND THEIR IMPACT ON FUTURE PERSPECTIVES IN ESTROGEN THERAPY | 2004年 / 46卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：47 / 62
页数：16
相关论文
共 50 条
  • [1] Structure-based design of estrogen receptor-beta selective compounds
    Malamas, Michael S.
    Harris, Heather A.
    Keith, Jim
    McDevitt, Bob
    Gunawan, Iwan
    Manas, Eric
    Miller, Christopher P.
    Mewshaw, Richard E.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 232 : 310 - 310
  • [2] Structure-based design of estrogen receptor-β selective ligands
    Manas, ES
    Unwalla, RJ
    Xu, ZB
    Malamas, MS
    Miller, CP
    Harris, HA
    Hsiao, C
    Akopian, T
    Hum, WT
    Malakian, K
    Wolfrom, S
    Bapat, A
    Bhat, RA
    Stahl, ML
    Somers, WS
    Alvarez, JC
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (46) : 15106 - 15119
  • [3] Dissecting physiological roles of estrogen receptor alpha and beta with selective Ligands from protein structure-based design.
    Hillisch, A
    Peters, O
    Müller, G
    Kosemund, D
    Elger, W
    Hegele-Hartung, C
    Fritzemeier, KH
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (11) : 2780S - 2781S
  • [4] Dissecting physiological roles of estrogen receptor α and β with potent selective ligands from structure-based design
    Hillisch, A
    Peters, O
    Kosemund, D
    Müller, G
    Walter, A
    Schneider, B
    Reddersen, G
    Elger, W
    Fritzemeier, KH
    [J]. MOLECULAR ENDOCRINOLOGY, 2004, 18 (07) : 1599 - 1609
  • [5] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy
    Demizu, Yosuke
    Okuhira, Keiichiro
    Motoi, Hiromi
    Ohno, Akiko
    Shoda, Takuji
    Fukuhara, Kiyoshi
    Okuda, Haruhiro
    Naito, Mikihiko
    Kurihara, Masaaki
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (04) : 1793 - 1796
  • [6] Structure-Based Approach for the Discovery of Novel Selective Estrogen Receptor Modulators
    Rosano, C.
    Stec-Martyna, E.
    Lappano, R.
    Maggiolini, M.
    [J]. CURRENT MEDICINAL CHEMISTRY, 2011, 18 (08) : 1188 - 1194
  • [7] Structure-Based Design, Synthesis, and Biochemical and Pharmacological Characterization of Novel Salvinorin A Analogues as Active State Probes of the κ-Opioid Receptor
    Yan, Feng
    Bikbulatov, Ruslan V.
    Mocanu, Viorel
    Dicheva, Nedyalka
    Parker, Carol E.
    Wetsel, William C.
    Mosier, Philip D.
    Westkaemper, Richard B.
    Allen, John A.
    Zjawiony, Jordan K.
    Roth, Bryan L.
    [J]. BIOCHEMISTRY, 2009, 48 (29) : 6898 - 6908
  • [8] A protein crystallization strategy for structure-based drug design
    Bergfors, Terese
    [J]. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2019, 75 : A46 - A46
  • [9] Structure-based design, synthesis, and evaluation of benzopyrans as selective estrogen receptor-beta agonists for the treatment of benign prostatic hyperplasia
    Richardson, Timothy I.
    Shah, Jikesh
    Norman, Bryan H.
    Kroin, Julian S.
    Thomas, Elizabeth M.
    Dodge, Jeffrey A.
    Lugar, Charles W.
    Jones, Scott A.
    Pfeifer, Lance A.
    Borromeo, Peter S.
    Durst, Gregory L.
    Wang, Yong Y.
    Durbin, Jim D.
    Montrose-Rafizadeh, Chahrzad
    Barr, Robert J.
    Osborne, Harold E.
    Amos, Robert M.
    Chen, Keyue
    Krishnan, Venkatesh
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 620 - 620
  • [10] Structure-based design of eugenol analogs as potential estrogen receptor antagonists
    Anita, Yulia
    Radifar, Muhammad
    Kardono, Leonardus B. S.
    Hanafi, Muhammad
    Istyastono, Enade P.
    [J]. BIOINFORMATION, 2012, 8 (19) : 901 - 906
12345