Structure-based design of estrogen receptor-beta selective compounds

被引:0
|
作者
Malamas, Michael S. [1 ]
Harris, Heather A. [2 ]
Keith, Jim [3 ]
McDevitt, Bob [1 ]
Gunawan, Iwan [1 ]
Manas, Eric [4 ]
Miller, Christopher P. [5 ]
Mewshaw, Richard E. [6 ]
机构
[1] Wyeth Ayerst Res, Chem & Screening Sci, Princeton, NJ 08543 USA
[2] Wyeth Res, Womens Hlth Res Inst, Collegeville, PA 19426 USA
[3] Wyeth Res, Dept Cardiovasc & Metab Dis, Cambridge, MA 02140 USA
[4] TransForm Pharmaceut Inc, Lexington, MA 02421 USA
[5] Wyeth Res, Patent Dept, Collegeville, PA 19426 USA
[6] Wyeth Res, Chem & Srceening Sci, Collegeville, PA 19426 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
37-COMP
引用
收藏
页码:310 / 310
页数:1
相关论文
共 50 条
  • [1] Structure-based design, synthesis, and evaluation of benzopyrans as selective estrogen receptor-beta agonists for the treatment of benign prostatic hyperplasia
    Richardson, Timothy I.
    Shah, Jikesh
    Norman, Bryan H.
    Kroin, Julian S.
    Thomas, Elizabeth M.
    Dodge, Jeffrey A.
    Lugar, Charles W.
    Jones, Scott A.
    Pfeifer, Lance A.
    Borromeo, Peter S.
    Durst, Gregory L.
    Wang, Yong Y.
    Durbin, Jim D.
    Montrose-Rafizadeh, Chahrzad
    Barr, Robert J.
    Osborne, Harold E.
    Amos, Robert M.
    Chen, Keyue
    Krishnan, Venkatesh
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 620 - 620
  • [2] Structure-based design of estrogen receptor-β selective ligands
    Manas, ES
    Unwalla, RJ
    Xu, ZB
    Malamas, MS
    Miller, CP
    Harris, HA
    Hsiao, C
    Akopian, T
    Hum, WT
    Malakian, K
    Wolfrom, S
    Bapat, A
    Bhat, RA
    Stahl, ML
    Somers, WS
    Alvarez, JC
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (46) : 15106 - 15119
  • [3] Protein structure-based design, synthesis strategy and in vitro pharmacological characterization of estrogen receptor α and β selective compounds
    Hillisch, A
    Peters, O
    Kosemund, D
    Müller, G
    Walter, A
    Elger, W
    Fritzemeier, KH
    [J]. NEW MOLECULAR MECHANISMS OF ESTROGEN ACTION AND THEIR IMPACT ON FUTURE PERSPECTIVES IN ESTROGEN THERAPY, 2004, 46 : 47 - 62
  • [4] Design, synthesis, and evaluation of naphthalene-based estrogen receptor-beta selective ligands.
    Mewshaw, RE
    Edsall, RJ
    Yang, CJ
    Manas, ES
    Keith, JC
    Leathurby, Y
    Alberta, LM
    Harris, HA
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U45 - U45
  • [5] Design and synthesis of carborane-containing estrogen receptor-beta (ERβ)-selective ligands
    Ohta, Kiminori
    Ogawa, Takumi
    Oda, Akifumi
    Kaise, Asako
    Endo, Yasuyuki
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (19) : 4174 - 4178
  • [6] Quantitative structure-activity relationships for a series of selective estrogen receptor-beta modulators
    Salum, L. B.
    Polikarpov, I.
    Andricopulo, A. D.
    [J]. SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2007, 18 (7-8) : 711 - 727
  • [7] Dissecting physiological roles of estrogen receptor alpha and beta with selective Ligands from protein structure-based design.
    Hillisch, A
    Peters, O
    Müller, G
    Kosemund, D
    Elger, W
    Hegele-Hartung, C
    Fritzemeier, KH
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (11) : 2780S - 2781S
  • [8] Dissecting physiological roles of estrogen receptor α and β with potent selective ligands from structure-based design
    Hillisch, A
    Peters, O
    Kosemund, D
    Müller, G
    Walter, A
    Schneider, B
    Reddersen, G
    Elger, W
    Fritzemeier, KH
    [J]. MOLECULAR ENDOCRINOLOGY, 2004, 18 (07) : 1599 - 1609
  • [9] Selective estrogen receptor-beta agonists are potent antiinflammatory agents.
    Malamas, MS
    Harris, HA
    Keith, JC
    McDevitt, B
    Gunawan, I
    Miller, CP
    Alberta, LM
    Leathurby, Y
    Manas, ES
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 226 : U38 - U39
  • [10] Structure-Based Approach for the Discovery of Novel Selective Estrogen Receptor Modulators
    Rosano, C.
    Stec-Martyna, E.
    Lappano, R.
    Maggiolini, M.
    [J]. CURRENT MEDICINAL CHEMISTRY, 2011, 18 (08) : 1188 - 1194