Synthesis and Antifungal Activity Against Candida Albicans of 6-Aryl-3,4-Dimethyl-N-Phenyl-2-Oxo-1,2,3,6-Tetrahydropyrimidine-5-Carboxamides

被引：0
|
作者：
Zamaraeva, T. M. [1 ]
Odegova, T. F. [1 ]
Fedotov, A. Yu. [1 ]
Tomilov, M. V. [1 ]
Gein, V. L. [1 ]
机构：
[1] Perm State Pharmaceut Acad, Perm 614990, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2015年 / 49卷 / 08期
关键词：
three-component synthesis; 3,4-dimethyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamide derivatives; antifungal activity;
D O I：
10.1007/s11094-015-1316-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
6-Aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides were synthesized by three-component reactions of acetoacetanilide, aromatic aldehydes, and N-methylurea. The structures of the compounds were confirmed by IR and PMR spectroscopy and mass spectrometry. The antifungal activity of the synthesized compounds was studied.
引用
收藏
页码：509 / 511
页数：3
相关论文
共 50 条
  • [21] Synthesis of N,6-diaryl-2-imino-4-methyl-3-cyano-1,2,3,6-tetrahydropyrimidine-5-carboxamides
    Gein, V. L.
    Zamaraeva, T. M.
    Buzmakova, N. A.
    Fedotov, A. Yu.
    Gein, L. F.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2015, 85 (06) : 1540 - 1543
  • [22] Synthesis of N,6-diaryl-2-imino-4-methyl-3-cyano-1,2,3,6-tetrahydropyrimidine-5-carboxamides
    V. L. Gein
    T. M. Zamaraeva
    N. A. Buzmakova
    A. Yu. Fedotov
    L. F. Gein
    Russian Journal of General Chemistry, 2015, 85 : 1540 - 1543
  • [23] Synthesis and structure of N,6-diaryl-4-methyl-2-cyanoimino-1,2,3,6-tetrahydropyrimidine-5-carboxamides
    V. L. Gein
    T. M. Zamaraeva
    M. V. Dmitriev
    Russian Journal of General Chemistry, 2017, 87 : 350 - 352
  • [24] Synthesis and Anti-Inflammatory Activity of N,6-Diaryl-4-Methyl-2-Thioxo-1,2,3,6-Tetrahydropyrimidine-5-Carboxamides
    N. A. Buzmakova
    I. P. Rudakova
    T. M. Zamaraeva
    Pharmaceutical Chemistry Journal, 2021, 55 : 775 - 777
  • [25] Synthesis and Anti-Inflammatory Activity of N,6-Diaryl-4-Methyl-2-Thioxo-1,2,3,6-Tetrahydropyrimidine-5-Carboxamides
    Buzmakova, N. A.
    Rudakova, I. P.
    Zamaraeva, T. M.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2021, 55 (08) : 775 - 777
  • [26] Three-component synthesis of 6-aryl-4-methyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-(N-aryl)carboxamides
    V. L. Gein
    T. M. Zamaraeva
    A. A. Kurbatova
    M. I. Vakhrin
    Chemistry of Heterocyclic Compounds, 2010, 46 : 856 - 858
  • [27] THREE-COMPONENT SYNTHESIS OF 6-ARYL-4-METHYL-2-OXO-1,2,3,6-TETRAHYDROPYRIMIDINE-5-(N-ARYL)CARBOXAMIDES
    Gein, V. L.
    Zamaraeva, T. M.
    Kurbatova, A. A.
    Vakhrin, M. I.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2010, 46 (07) : 856 - 858
  • [28] Synthesis of Diethyl 6-Aryl-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates
    Gein, V. L.
    Zamaraeva, T. M.
    Volkova, E. S.
    Dmitriev, M. V.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 52 (05) : 730 - 733
  • [29] Synthesis of diethyl 6-aryl-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates
    V. L. Gein
    T. M. Zamaraeva
    E. S. Volkova
    M. V. Dmitriev
    Russian Journal of Organic Chemistry, 2016, 52 : 730 - 733
  • [30] SYNTHESIS OF METHYL ESTERS OF 5-AROYL-6-ARYL-2-OXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACIDS
    Gein, V. L.
    Krylova, I. V.
    Tsypliakova, E. P.
    Gaifullina, A. R.
    Varkentin, L. I.
    Vakhrin, M. I.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2009, 45 (07) : 829 - 832
12345