Synthesis and Antifungal Activity Against Candida Albicans of 6-Aryl-3,4-Dimethyl-N-Phenyl-2-Oxo-1,2,3,6-Tetrahydropyrimidine-5-Carboxamides

被引：0
|
作者：
Zamaraeva, T. M. [1 ]
Odegova, T. F. [1 ]
Fedotov, A. Yu. [1 ]
Tomilov, M. V. [1 ]
Gein, V. L. [1 ]
机构：
[1] Perm State Pharmaceut Acad, Perm 614990, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2015年 / 49卷 / 08期
关键词：
three-component synthesis; 3,4-dimethyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamide derivatives; antifungal activity;
D O I：
10.1007/s11094-015-1316-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
6-Aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides were synthesized by three-component reactions of acetoacetanilide, aromatic aldehydes, and N-methylurea. The structures of the compounds were confirmed by IR and PMR spectroscopy and mass spectrometry. The antifungal activity of the synthesized compounds was studied.
引用
收藏
页码：509 / 511
页数：3
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