Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for gastric cancer

被引：13
|
作者：
Wang, Huiying [1 ]
Wang, Yingnan [1 ]
Zhao, Qun [2 ]
Guo, Zhanjun [1 ]
Zhang, Fengbin [1 ]
Zhao, Yue [1 ]
Zhang, Ruixing [1 ]
机构：
[1] Hebei Med Univ, Hosp 4, Dept Gastroenterol & Hepatol, Shijiazhuang 050011, Peoples R China
[2] Hebei Med Univ, Hosp 4, Dept Gen Surg, Shijiazhuang 050011, Peoples R China
来源：
MITOCHONDRIAL DNA PART A | 2016年 / 27卷 / 02期
关键词：
D-Loop; gastric cancer; mtDNA; SNPs;
D O I：
10.3109/19401736.2014.926546
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in different types of cancers. We investigated the gastric cancer risk profile of D-Loop SNPs in a case-control study. The frequent alleles of nucleotides 73G/A, 235A/G, 309C/C insert, 324C/G, 16,362T/C and 16,519C/T were significantly associated with an increased risk for gastric cancer, whereas the frequent alleles of nucleotides 523-524AC/del were associated with resistance to gastric cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for gastric cancer risk evaluation.
引用
收藏
页码：1045 / 1047
页数：3
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