Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for gastric cancer

被引：13

作者：

Wang, Huiying ^{[1
]}

Wang, Yingnan ^{[1
]}

Zhao, Qun ^{[2
]}

Guo, Zhanjun ^{[1
]}

Zhang, Fengbin ^{[1
]}

Zhao, Yue ^{[1
]}

Zhang, Ruixing ^{[1
]}

机构：

[1] Hebei Med Univ, Hosp 4, Dept Gastroenterol & Hepatol, Shijiazhuang 050011, Peoples R China

[2] Hebei Med Univ, Hosp 4, Dept Gen Surg, Shijiazhuang 050011, Peoples R China

来源：

MITOCHONDRIAL DNA PART A | 2016年 / 27卷 / 02期

关键词：

D-Loop; gastric cancer; mtDNA; SNPs;

D O I：

10.3109/19401736.2014.926546

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in different types of cancers. We investigated the gastric cancer risk profile of D-Loop SNPs in a case-control study. The frequent alleles of nucleotides 73G/A, 235A/G, 309C/C insert, 324C/G, 16,362T/C and 16,519C/T were significantly associated with an increased risk for gastric cancer, whereas the frequent alleles of nucleotides 523-524AC/del were associated with resistance to gastric cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for gastric cancer risk evaluation.

引用

页码：1045 / 1047

页数：3

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