Comparison of Patients Hospitalized With Influenza A Subtypes H7N9, H5N1, and 2009 Pandemic H1N1

被引:99
|
作者
Wang, Chen [1 ,2 ,3 ,4 ]
Yu, Hongjie [5 ]
Horby, Peter W. [6 ,7 ,8 ]
Cao, Bin [9 ]
Wu, Peng [10 ]
Yang, Shigui [11 ,12 ]
Gao, Hainv [11 ,12 ]
Li, Hui [9 ]
Tsang, Tim K. [10 ]
Liao, Qiaohong [5 ]
Gao, Zhancheng [13 ]
Ip, Dennis K. M. [10 ]
Jia, Hongyu [11 ,12 ]
Jiang, Hui [5 ]
Liu, Bo [9 ]
Ni, Michael Y. [10 ]
Dai, Xiahong [11 ,12 ]
Liu, Fengfeng [5 ]
Nguyen Van Kinh [14 ]
Nguyen Thanh Liem [15 ]
Tran Tinh Hien [6 ,16 ]
Li, Yu [5 ]
Yang, Juan [5 ]
Wu, Joseph T. [10 ]
Zheng, Yaming [5 ]
Leung, Gabriel M. [10 ]
Farrar, Jeremy J. [6 ,7 ,8 ,17 ]
Cowling, Benjamin J. [10 ]
Uyeki, Timothy M. [18 ]
Li, Lanjuan [11 ,12 ]
机构
[1] Capital Med Univ, Inst Resp Med, Beijing Hosp, Natl Hlth & Family Planning Commiss, Beijing, Peoples R China
[2] Capital Med Univ, Dept Resp Med, Beijing, Peoples R China
[3] Chinese Ctr Dis Control & Prevent, Beijing Inst Resp Med, Beijing, Peoples R China
[4] Chinese Ctr Dis Control & Prevent, Beijing Key Lab Resp & Pulm Circulat Disorders, Beijing, Peoples R China
[5] Chinese Ctr Dis Control & Prevent, Div Infect Dis, Key Lab Surveillance & Early Warning Infect Dis, Beijing, Peoples R China
[6] Univ Oxford, Clin Res Unit, Wellcome Trust Major Overseas Programme, Hanoi, Vietnam
[7] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England
[8] Capital Med Univ, Singapore Infect Dis Initiat, Beijing, Peoples R China
[9] Capital Med Univ, Beijing Inst Resp Med, Beijing Chao Yang Hosp, Beijing, Peoples R China
[10] Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, Div Epidemiol & Biostat, Hong Kong, Hong Kong, Peoples R China
[11] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China
[12] Zhejiang Univ, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Dept Infect Dis,Coll Med, Hangzhou 310003, Zhejiang, Peoples R China
[13] Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100871, Peoples R China
[14] Natl Hosp Trop Dis, Hanoi, Vietnam
[15] Natl Hosp Pediat, Hanoi, Vietnam
[16] Hosp Trop Dis, Ho Chi Minh City, Vietnam
[17] Univ Oxford, Churchill Hosp, Ctr Trop Med, ISARIC, Oxford, England
[18] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA
基金
美国国家卫生研究院; 英国惠康基金; 中国国家自然科学基金;
关键词
influenza A(H7N9); influenza A(H5N1); clinical epidemiology; VIRUS-INFECTION; A(H7N9) VIRUS; CHINA; DISEASE; PREVALENCE; FERRETS; POPULATION; HUMANS; TRANSMISSION; PATHOGENESIS;
D O I
10.1093/cid/ciu053
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Influenza A(H7N9) viruses isolated from humans show features suggesting partial adaptation to mammals. To provide insights into the pathogenesis of H7N9 virus infection, we compared risk factors, clinical presentation, and progression of patients hospitalized with H7N9, H5N1, and 2009 pandemic H1N1 (pH1N1) virus infections. Methods. We compared individual-level data from patients hospitalized with infection by H7N9 (n = 123), H5N1 (n = 119; 43 China, 76 Vietnam), and pH1N1 (n = 3486) viruses. We assessed risk factors for hospitalization after adjustment for age-and sex-specific prevalence of risk factors in the general Chinese population. Results. The median age of patients with H7N9 virus infection was older than other patient groups (63 years; P <.001) and a higher proportion was male (71%; P <.02). After adjustment for age and sex, chronic heart disease was associated with an increased risk of hospitalization with H7N9 (relative risk, 9.68; 95% confidence interval, 5.24-17.9). H7N9 patients had similar patterns of leukopenia, thrombocytopenia, and elevated alanine aminotransferase, creatinine kinase, C-reactive protein, and lactate dehydrogenase to those seen in H5N1 patients, which were all significantly different from pH1N1 patients (P <.005). H7N9 patients had a longer duration of hospitalization than either H5N1 or pH1N1 patients (P <.001), and the median time from onset to death was 18 days for H7N9 (P =.002) vs 11 days for H5N1 and 15 days for pH1N1 (P =.154). Conclusions. The identification of known risk factors for severe seasonal influenza and the more protracted clinical course compared with that of H5N1 suggests that host factors are an important contributor to H7N9 severity.
引用
收藏
页码:1095 / 1103
页数:9
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