H7N9 Influenza Virus Is More Virulent in Ferrets than 2009 Pandemic H1N1 Influenza Virus

被引:7
|
作者
Yum, Jung [1 ,2 ]
Ku, Keun Bon [1 ,2 ]
Kim, Hyun Soo [3 ]
Seo, Sang Heui [1 ,2 ]
机构
[1] Chungnam Natl Univ, Coll Vet Med, Lab Influenza Res, Taejon 305764, South Korea
[2] Chungnam Natl Univ, Inst Influenza Virus, Coll Vet Med, Taejon 305764, South Korea
[3] Chungnam Natl Univ, Coll Vet Med, Publ Hlth Lab, Taejon 305764, South Korea
关键词
SWINE-ORIGIN; 2009; A VIRUSES; PATHOGENICITY; TRANSMISSION; INFECTION;
D O I
10.1089/vim.2015.0052
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The novel H7N9 influenza virus has been infecting humans in China since February 2013 and with a mortality rate of about 40%. This study compared the pathogenicity of the H7N9 and 2009 pandemic H1N1 influenza viruses in a ferret model, which shows similar symptoms to those of humans infected with influenza viruses. The H7N9 influenza virus caused a more severe disease than did the 2009 pandemic H1N1 influenza virus. All of the ferrets infected with the H7N9 influenza virus had died by 6 days after infection, while none of those infected with the 2009 pandemic H1N1 influenza virus died. Ferrets infected with the H7N9 influenza virus had higher viral titers in their lungs than did those infected with the 2009 pandemic H1N1 influenza virus. Histological findings indicated that hemorrhagic pneumonia was caused by infection with the H7N9 influenza virus, but not with the 2009 pandemic H1N1 influenza virus. In addition, the lung tissues of ferrets infected with the H7N9 influenza virus contained higher levels of chemokines than did those of ferrets infected with the 2009 pandemic H1N1 influenza virus. This study suggests that close monitoring is needed to prevent human infection by the lethal H7N9 influenza virus.
引用
收藏
页码:590 / 599
页数:10
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